Dickkopf-3: a stubborn protector of cardiac hypertrophy
نویسندگان
چکیده
منابع مشابه
Dickkopf-3: a stubborn protector of cardiac hypertrophy.
In response to haemodynamic overload under pathological conditions such as hypertension, valvular heart disease, and myocardial infarction, the heart undergoes hypertrophic growth by increasing cell size and protein synthesis as well as changing the transcriptional programme in cardiac myocytes. Although cardiac hypertrophy is beneficial in the way that it reduces ventricular wall tension and m...
متن کاملDetection of Cardiac Hypertrophy by RVM and SVM Algorithms
The meaning of the hypertropy word is the increasing size.Heart hypertropy is symptoms of increase the thickness of the heart muscle that the left ventricular hypertrophy of them is the most common.The causes of hypertrophy heart disease are high blood pressure , aortic valve stenosis and sport activities respectively. Assessment of that by using ECG signal analysis is essential Because the ris...
متن کاملDawn simulation light: a potential cardiac events protector.
OBJECTIVE/BACKGROUND Major cardiovascular events frequently increase in the morning due to abrupt changes in the sympatho-vagal cardiac control during the transition from sleep to wakefulness. These neural changes are translated into stepwise increases in cardiac functions, resulting in a potential cardiovascular stress. Here, we explored whether light can "optimize" heart rate and its neural c...
متن کاملActivated glycogen synthase-3 suppresses cardiac hypertrophy in vivo
The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium calmodulin-dependent protein phosphatase calcineurin is a potent transducer of hypertrophic stimuli. Calcineurin dephosphorylates members of the nuclear factor of activated T cell (NFAT) family of transcription factors, which results in their transloca...
متن کاملA Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective
BACKGROUND Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is known about its role in atherosclerosis. METHODS We tested the hypothesis that DKK3 is atheroprotective using both epidemiological and experimental approaches. Blood DKK3 levels were measured in the Bruneck S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2014
ISSN: 0008-6363
DOI: 10.1093/cvr/cvu051